Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186762 | 0.84 | PTGS1 (0.62) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL27811591 | 0.82 | KEAP1 (0.52) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL4866296 | 0.81 | KEAP1 (0.50) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL19567904 | 0.81 | KEAP1 (0.50) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL4963565 | 0.81 | KEAP1 (0.55) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL8420054 | 0.80 | KEAP1 (0.46) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15225007 | 0.79 | KEAP1 (0.49) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL3715386 | 0.79 | PLA2G7 (0.54) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL2068498 | 0.79 | KEAP1 (0.65) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 | |
| SCHEMBL29904739 | 0.79 | KEAP1 (0.65) | KEAP1L3MBTL1PTGS1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |