Sugi Predict

Sugi Predict / Compounds / SCHEMBL4963565

SCHEMBL4963565

SCHEMBL4963565

CS(=O)(=O)Nc1ccccc1CO

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 3/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ EP300 Q09472 1/20 0.51
▸ KAT2B Q92831 1/20 0.51
▸ KAT8 Q9H7Z6 1/20 0.51
▸ ALDH1A1 P00352 6/20 0.50
▸ KDM4E B2RXH2 4/20 0.49
▸ NR3C1 P04150 1/20 0.49
▸ RCE1 Q9Y256 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ PTGS1 P23219 1/20 0.48
▸ NFE2L2 Q16236 1/20 0.47
▸ HPGD P15428 4/20 0.47
▸ HSD17B10 Q99714 2/20 0.47
▸ GAA P10253 1/20 0.46
▸ PLA2G7 Q13093 2/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ NQO2 P16083 1/20 0.44
▸ TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5186762 0.84 PTGS1 (0.62) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL27811591 0.82 KEAP1 (0.52) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL8867626 0.82 PIK3CG (0.49) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL9472767 0.81 ALDH1A1 (0.51) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL8709063 0.81 KEAP1 (0.50) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL19567904 0.81 KEAP1 (0.50) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL4866296 0.81 KEAP1 (0.50) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL11154970 0.80 ALDH1A1 (0.50) KEAP1L3MBTL1EP300KAT2BKAT8
SCHEMBL7888388 0.80 PTGS2 (0.54) KEAP1L3MBTL1ALDH1A1KDM4ERCE1
SCHEMBL9329237 0.79 SLC16A3 (0.48) ALDH1A1KMT2AHPGDHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115151553-A Boronic acid derivatives 首药控股(北京)股份有限公司 2022-10-04 — — CN disclosed
US-11078233-B2 Tripeptide epoxy ketone protease inhibitors ONYX THERAPEUTICS, INC. (US) 2021-08-03 — — US disclosed
US-11078233-B2 Tripeptide epoxy ketone protease inhibitors ONYX THERAPEUTICS, INC. (US) 2021-08-03 — — US disclosed
WO-2021143923-A1 BORONIC ACID DERIVATIVES 首药控股(北京)股份有限公司 2021-07-22 — — WO disclosed
US-20200207809-A1 TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS ONYX THERAPEUTICS, INC. 2020-07-02 — — US disclosed
US-20200207809-A1 TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS ONYX THERAPEUTICS, INC. 2020-07-02 — — US disclosed
US-10647744-B2 Tripeptide epoxy ketone protease inhibitors ONYX THERAPEUTICS, INC. (US) 2020-05-12 — — US disclosed
US-10647744-B2 Tripeptide epoxy ketone protease inhibitors ONYX THERAPEUTICS, INC. (US) 2020-05-12 — — US disclosed
US-10383880-B2 Carbazole-containing sulfonamides as cryptochrome modulators Synchronicity (US) 2019-08-20 — — US disclosed
US-10383880-B2 Carbazole-containing sulfonamides as cryptochrome modulators Synchronicity (US) 2019-08-20 — — US disclosed
WO-2014152134-A1 TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS ONYX THERAPEUTICS, INC. (US) 2014-09-25 — — WO disclosed
US-20130303524-A1 Carbazole-Containing Sulfonamides as Cryptochrome Modulators Synchronicity Pharma, Inc. 2013-11-14 — — US disclosed
WO-2013170186-A1 CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS RESET THERAPEUTICS, INC. (US) 2013-11-14 — — WO disclosed
US-20130303524-A1 Carbazole-Containing Sulfonamides as Cryptochrome Modulators Synchronicity Pharma, Inc. 2013-11-14 — — US disclosed
US-20130303524-A1 Carbazole-Containing Sulfonamides as Cryptochrome Modulators Synchronicity Pharma, Inc. 2013-11-14 — — US disclosed
US-20080171737-A1 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-07-17 — — US disclosed
US-20080171737-A1 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-07-17 — — US disclosed
US-20080171737-A1 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-07-17 — — US disclosed
WO-2008073956-A2 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-06-19 — — WO disclosed
WO-2008073956-A2 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-06-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11078233-B2 Tripeptide epoxy ketone protease inhibitors PREP, CTRL, ENPEP KEAP1 110/4885L3MBTL1 3358/4885EP300 1113/4885
US-20130303524-A1 Carbazole-Containing Sulfonamides as Cryptochrome Modulators CRY1, CRY2, CRYAB KEAP1 571/4885L3MBTL1 4350/4885EP300 3179/4885
US-10383880-B2 Carbazole-containing sulfonamides as cryptochrome modulators CRY1, CRY2, CRYAB KEAP1 468/4885L3MBTL1 4425/4885EP300 3256/4885
US-20080171737-A1 CYCLIC SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE SLC6A4, SLC6A2, SLC6A3 KEAP1 1790/4885L3MBTL1 4757/4885EP300 4863/4885
US-20200207809-A1 TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS PREP, CTRL, ENPEP KEAP1 110/4885L3MBTL1 3358/4885EP300 1113/4885
US-10647744-B2 Tripeptide epoxy ketone protease inhibitors PREP, CTRL, ENPEP KEAP1 110/4885L3MBTL1 3358/4885EP300 1113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.