SCHEMBL8709228

SCHEMBL8709228

CCOP(=O)(COCOCn1cnc2c(Cl)nc(N)nc21)OCC

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 19/20 0.47
HSP90AA1 P07900 18/20 0.47
HSP90B1 P14625 1/20 0.43
TRAP1 Q12931 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400863 0.87 SLC22A6 (0.47) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4
SCHEMBL6836055 0.83 HSP90AB1 (0.44) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4
SCHEMBL6836050 0.83 HSP90AB1 (0.44) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4
SCHEMBL6833575 0.83 HSP90AB1 (0.44) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4
SCHEMBL6831092 0.83 HSP90AB1 (0.44) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4
SCHEMBL8713496 0.83 ACHE (0.40) HSP90AB1HSP90AA1HDAC4HDAC1HDAC6
SCHEMBL23223510 0.81 FAP (0.48) HSP90AB1HSP90AA1HDAC4HDAC1HDAC6
SCHEMBL17194161 0.81 FAP (0.48) HSP90AB1HSP90AA1HDAC4HDAC1HDAC6
SCHEMBL8709070 0.80 FAP (0.56)
SCHEMBL14621498 0.79 SLC22A6 (0.46) HSP90AB1HSP90AA1HSP90B1TRAP1HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5837871-A PHOSPHONATE DERIVATIVES; ANTITUMOR AGENTS, VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-11-17 US disclosed
US-5726174-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-03-10 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5693798-A ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-02 US disclosed
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed
EP-0398231-B1 Nucleoside analogs ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-07-16 EP disclosed