Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476522 | 0.79 | AKR1C3 (0.39) | BCL2MCL1AKR1C2AKR1C1MAPT | |
| SCHEMBL29260299 | 0.78 | LMNA (0.60) | BCL2MCL1AKR1C2AKR1C1MAPT | |
| SCHEMBL11562388 | 0.77 | AKR1C3 (0.56) | BCL2MCL1MAPTKDM4EMAPK1 | |
| SCHEMBL8132106 | 0.74 | AKR1C2 (0.45) | AKR1C2AKR1C1MAPTKDM4EMAPK1 | |
| SCHEMBL5058309 | 0.73 | AKR1C3 (0.55) | BCL2MCL1MAPTKDM4EHSD17B10 | |
| SCHEMBL8710436 | 0.73 | ALDH1A1 (0.52) | MCL1AKR1C2AKR1C1KDM4EHSD17B10 | |
| SCHEMBL5712155 | 0.71 | BCL2 (0.57) | BCL2MCL1MAPTKDM4EMAPK1 | |
| Benzophenone SCHEMBL5389322 | 0.70 | ALDH1A1 (0.61) | MAPTKDM4EMAPK1HSD17B10LMNA | |
| SCHEMBL15020131 | 0.70 | ANPEP (0.51) | MAPTKDM4EMAPK1HSD17B10AKR1C3 | |
| SCHEMBL7614569 | 0.70 | BCL2 (0.56) | BCL2MCL1MAPTKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |