Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043271 | 0.84 | ALPG (0.45) | TSHRCYP3A4ALDH1A1HTTKMT2A | |
| SCHEMBL8710522 | 0.83 | TP53 (0.46) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8046022 | 0.82 | TP53 (0.45) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8052238 | 0.80 | POLB (0.45) | TSHRHTTNPC1RAB9AKMT2A | |
| SCHEMBL8034049 | 0.79 | TSHR (0.58) | TSHRCYP3A4CYP2C19ALDH1A1HTT | |
| SCHEMBL8043019 | 0.79 | HDAC6 (0.38) | TSHRCYP3A4CYP2C19ALDH1A1HTT | |
| SCHEMBL8050243 | 0.78 | NPSR1 (0.57) | TSHRCYP3A4CYP2C19ALDH1A1HTT | |
| SCHEMBL8044835 | 0.78 | USP7 (0.38) | TSHRCYP2C19ALDH1A1HTTKMT2A | |
| SCHEMBL8719307 | 0.78 | TP53 (0.48) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8044462 | 0.77 | ALDH1A1 (0.48) | TSHRCYP3A4CYP2C19ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |