Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710954 | 1.00 | TSHR (0.44) | TSHRHPGDMAPTCYP1A2CYP2C9 | |
| SCHEMBL8709297 | 0.88 | TSHR (0.38) | TSHRCYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL8710268 | 0.79 | XDH (0.43) | MAPTKMT2ANPC1POLBMEN1 | |
| SCHEMBL8710175 | 0.76 | KDM4E (0.36) | CYP1A2CYP2C9CYP2C19KMT2ANPC1 | |
| SCHEMBL8709054 | 0.71 | CYP3A4 (0.47) | TSHRMAPTCYP2C9CYP2C19CYP3A4 | |
| SCHEMBL4212506 | 0.70 | NPC1 (0.53) | TSHRMAPTKMT2ANPC1MEN1 | |
| SCHEMBL3142232 | 0.69 | ABL1 (0.51) | TSHRMAPTKMT2AMEN1LMNA | |
| SCHEMBL8715277 | 0.68 | CLCN2 (0.38) | MAPTKMT2APOLBMEN1RAB9A | |
| SCHEMBL8712836 | 0.68 | MAPK8 (0.37) | HPGDKMT2ANPC1POLBMEN1 | |
| SCHEMBL8713191 | 0.68 | MAPK8 (0.39) | HPGDKMT2ANPC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |