Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712836 | 0.95 | MAPK8 (0.37) | MAPK8CLCN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8709890 | 0.90 | RAB9A (0.37) | MAPK8RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8709365 | 0.86 | GRM4 (0.37) | MAPK8CLCN2RAB9AALDH1A1TDP1 | |
| SCHEMBL8715277 | 0.86 | CLCN2 (0.38) | MAPK8CLCN2RAB9AALDH1A1KMT2A | |
| SCHEMBL8709579 | 0.84 | KDM4E (0.38) | MAPK8RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL8709273 | 0.83 | XDH (0.40) | CLCN2RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8709829 | 0.83 | XDH (0.40) | RAB9ANPC1LMNAPOLBDHODH | |
| SCHEMBL8712687 | 0.83 | POLB (0.38) | CLCN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL8710521 | 0.82 | CNR2 (0.36) | MAPK8CLCN2RAB9AALDH1A1KMT2A | |
| SCHEMBL8713114 | 0.82 | CLCN2 (0.39) | CLCN2ALDH1A1HTR1ADRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |