Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872943 | 0.92 | POLB (0.71) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8708189 | 0.91 | POLB (0.57) | POLBNPC1RAB9AKMT2AMEN1 | |
| Imidazole SCHEMBL9873212 | 0.88 | POLB (0.48) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3028929 | 0.85 | NPC1 (0.54) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL10489859 | 0.85 | KDM4E (0.60) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL9873218 | 0.82 | POLB (0.48) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6844761 | 0.80 | POLB (0.58) | POLBKMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL9872897 | 0.78 | POLB (0.49) | POLBKCNH2DRD4DRD3 | |
| SCHEMBL9872901 | 0.78 | POLB (0.49) | POLBKCNH2DRD4DRD3 | |
| SCHEMBL8366392 | 0.78 | KDM4E (0.43) | POLBNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783702-A | Preparation of cisapride | TORCAN CHEMICAL LTD. (CA) | 1998-07-21 | — | — | US | disclosed |
| US-5665884-A | Preparation of cisapride | TORCAN CHEMICAL LTD. (CA) | 1997-09-09 | — | — | US | disclosed |
| US-5585387-A | Prepration of cisapride | TORCAN CHEMICAL LTD. (CA) | 1996-12-17 | — | — | US | disclosed |
| WO-1996011186-A1 | PREPARATION OF CISAPRIDE | TORCAN CHEMICAL LTD. (CA) | 1996-04-18 | — | — | WO | disclosed |
| US-5017582-A | Analgesics | SANDOZ LTD. (CH) | 1991-05-21 | — | — | US | disclosed |
| US-4910207-A | Antipsychotic agent | NOVARTIS AG (CH) | 1990-03-20 | — | — | US | disclosed |
| US-4803199-A | SEROTONIN ANTAGONIST, ANALGESIC ANTIARRHYTHMIC AGENTS | NOVARTIS AG (CH) | 1989-02-07 | — | — | US | disclosed |
| WO-1984000166-A1 | BENZOIC ACID PIPERIDYL ESTER DERIVATIVES AND METHOD OF PRODUCTION AND UTILIZATION THEREOF | SANDOZ AG (CH) | 1984-01-19 | — | — | WO | disclosed |