Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711005 | 0.82 | POLB (0.60) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL9872943 | 0.81 | POLB (0.71) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL8708189 | 0.80 | POLB (0.57) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL9459218 | 0.79 | LRRK2 (0.44) | DRD4DRD3DRD2HTT | |
| Imidazole SCHEMBL9873212 | 0.78 | POLB (0.48) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL3028929 | 0.75 | NPC1 (0.54) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL7706502 | 0.72 | GAA (0.55) | RAB9AALDH1A1CYP1A2CYP2C9LMNA | |
| SCHEMBL8710426 | 0.71 | NPC1 (0.52) | POLBKMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL9872897 | 0.71 | POLB (0.49) | POLBDRD4DRD3DRD2 | |
| SCHEMBL9872901 | 0.71 | POLB (0.49) | POLBDRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017582-A | Analgesics | SANDOZ LTD. (CH) | 1991-05-21 | — | — | US | disclosed |
| US-4910207-A | Antipsychotic agent | NOVARTIS AG (CH) | 1990-03-20 | — | — | US | disclosed |
| US-4803199-A | SEROTONIN ANTAGONIST, ANALGESIC ANTIARRHYTHMIC AGENTS | NOVARTIS AG (CH) | 1989-02-07 | — | — | US | disclosed |