SCHEMBL8711632

SCHEMBL8711632

CC(=O)Nc1nc(C(=O)N(c2ccccc2)c2ccccc2)c2[nH]cnc2n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NEK2 P51955 6/20 0.45
GDA Q9Y2T3 1/20 0.43
STAT3 P40763 3/20 0.41
CDK2 P24941 3/20 0.40
ADORA3 P0DMS8 3/20 0.39
ADORA1 P30542 1/20 0.39
CHEK1 O14757 1/20 0.39
AURKA O14965 1/20 0.39
CHEK2 O96017 1/20 0.39
ABL1 P00519 1/20 0.39
LCK P06239 1/20 0.39
FYN P06241 1/20 0.39
CDK1 P06493 1/20 0.39
LYN P07948 1/20 0.39
MET P08581 1/20 0.39
SRC P12931 1/20 0.39
RPS6KB1 P23443 1/20 0.39
MAPK3 P27361 1/20 0.39
MAPK1 P28482 1/20 0.39
AKT2 P31751 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8711624 0.82 ADORA3 (0.40) NEK2ADORA3ADORA1MAPK1
SCHEMBL536795 0.81 NEK2 (0.43) NEK2GDASTAT3CDK2ADORA3
SCHEMBL8715386 0.80 NEK2 (0.42) NEK2GDASTAT3CDK2ADORA3
SCHEMBL31506448 0.73 GDA (0.55) NEK2GDASTAT3ADORA3AURKA
SCHEMBL887125 0.73 GDA (0.55) NEK2GDASTAT3SRCBRAF
SCHEMBL750335 0.73 GDA (0.55) NEK2GDASTAT3ADORA3AURKA
SCHEMBL3303363 0.72 PIN1 (0.59) GDASTAT3CDK2CDK1BRD4
SCHEMBL14938904 0.72 GDA (0.54) NEK2GDASRCBRAF
SCHEMBL5197101 0.72 GDA (0.54) NEK2GDASTAT3SRCBRAF
SCHEMBL803116 0.68 NPSR1 (0.41) ADORA3ADORA1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US claimed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US claimed
US-5837871-A PHOSPHONATE DERIVATIVES; ANTITUMOR AGENTS, VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-11-17 US disclosed
US-5726174-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-03-10 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5693798-A ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-02 US disclosed
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed
EP-0398231-B1 Nucleoside analogs ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1997-07-16 EP disclosed
EP-0398231-A2 Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1990-11-22 EP disclosed