SCHEMBL887125

SCHEMBL887125

CC(=O)Nc1nc(O)c2[nH]cnc2n1

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.55
NEK2 P51955 3/20 0.46
BRAF P15056 1/20 0.44
SRC P12931 3/20 0.40
PIK3CA P42336 1/20 0.40
MTOR P42345 1/20 0.40
MGMT P16455 1/20 0.40
CYP1A2 P05177 1/20 0.39
CDC7 O00311 1/20 0.39
DBF4 Q9UBU7 1/20 0.39
STAT3 P40763 4/20 0.39
POLB P06746 1/20 0.38
KDR P35968 1/20 0.37
AURKB Q96GD4 1/20 0.37
PTK2 Q05397 1/20 0.37
BTK Q06187 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31506448 0.84 GDA (0.55) GDANEK2BRAFSRCPIK3CA
SCHEMBL750335 0.84 GDA (0.55) GDANEK2BRAFSRCPIK3CA
SCHEMBL4777463 0.84 GDA (0.42) GDANEK2CYP1A2STAT3KDR
SCHEMBL5197101 0.83 GDA (0.54) GDANEK2BRAFSRCPIK3CA
SCHEMBL14938904 0.83 GDA (0.54) GDANEK2BRAFSRCMGMT
SCHEMBL9412640 0.81 GDA (0.39) GDANEK2STAT3KDRAURKB
SCHEMBL9412617 0.81 GDA (0.39) GDANEK2STAT3KDRAURKB
SCHEMBL377763 0.80 CDK2 (0.48) GDANEK2SRC
SCHEMBL12841391 0.77 STAT3 (0.47) NEK2SRCSTAT3BTK
SCHEMBL4945758 0.76 GDA (0.50) GDANEK2BRAFSRCPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP claimed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP claimed
US-20240368505-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF Tan Kah Kee Innovation Laboratory (CN) 2024-11-07 US claimed
WO-2023133876-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF 嘉庚创新实验室 2023-07-20 WO claimed
CN-111777611-B Preparation method of acyclovir intermediate N (2), 9-diacetylguanine 潍坊奥通药业有限公司 2022-11-04 CN claimed
US-20220195497-A1 HYBRIDIZING all-LNA OLIGONUCLEOTIDES ROCHE DIAGNOSTICS OPERATIONS, INC. 2022-06-23 US claimed
CN-113292564-B Synthetic method of 2-amino-6-chloropurine 上海凌凯医药科技有限公司 2022-04-19 CN claimed
EP-3980554-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2022-04-13 EP claimed
CN-114317127-A Fluoride-free cleaning agent, and preparation method and application thereof 嘉庚创新实验室 2022-04-12 CN claimed
CN-113939599-A Hybrid all-LNA oligonucleotides 豪夫迈·罗氏有限公司 2022-01-14 CN claimed
CN-113292564-A Synthetic method of 2-amino-6-chloropurine 上海凌凯医药科技有限公司 2021-08-24 CN claimed
WO-2020245377-A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. HOFFMANN-LA ROCHE AG (CH) 2020-12-10 WO claimed
CN-111777611-A Preparation method of acyclovir intermediate N (2), 9-diacetylguanine 潍坊奥通药业有限公司 2020-10-16 CN claimed
EP-4560315-A2 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES F. Hoffmann-La Roche AG (CH) 2025-05-28 EP disclosed
EP-3980554-B1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES HOFFMANN LA ROCHE (CH) 2025-03-26 EP disclosed
US-20240368505-A1 FLUORINE-FREE CLEANING AGENT, PREPARATION METHOD THEREFOR AND USE THEREOF Tan Kah Kee Innovation Laboratory (CN) 2024-11-07 US disclosed
US-4594321-A Reacting guanine derivative with phosphate YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US disclosed
US-4594320-A Reacting guanine derivative with phosphate compound YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US disclosed
EP-0152091-A2 Method for improving the selective inhibition of the activity of human pancreatic and salivary amylase and an inhibitor preparation therefore GÖDECKE AKTIENGESELLSCHAFT (DE) 1985-08-21 EP disclosed
EP-0090417-A2 Process for producing 3'-deoxyguanosine Yamasa Shoyu Kabushiki Kaisha (JP) 1983-10-05 EP disclosed