Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 4/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717511 | 0.89 | LMNA (0.41) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL253253 | 0.78 | FDPS (0.56) | FDPS | |
| SCHEMBL1815322 | 0.74 | FDPS (0.61) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL3228691 | 0.72 | LAP3 (0.44) | FDPS | |
| SCHEMBL7108948 | 0.72 | APP (0.46) | LMNABLMPMP22APPALDH1A1 | |
| SCHEMBL11359987 | 0.70 | LAP3 (0.61) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL16237440 | 0.70 | LMNA (0.50) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL8600008 | 0.70 | FDPS (0.60) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL4729598 | 0.70 | APP (0.44) | LMNABLMPMP22APPALDH1A1 | |
| SCHEMBL7028928 | 0.68 | TP53 (0.43) | LMNABLMPMP22APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642518-B1 | PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMA (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5731299-A | OSTEOPOROSIS; RHEUMATOID ARTHRITIS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-24 | — | — | US | disclosed |
| EP-0642518-A1 | PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024495-A1 | PHOSPHONOSULFONATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |