Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOX1 | Q06278 | 1/20 | 0.71 |
| ▸ | RAD52 | P43351 | 7/20 | 0.63 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.60 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | POLR1A | O95602 | 2/20 | 0.48 |
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105276 | 0.94 | AOX1 (0.78) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| SCHEMBL29369424 | 0.94 | AOX1 (0.78) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| Hydrochloric Acid SCHEMBL29608361 | 0.93 | AOX1 (0.77) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| Hydrochloric Acid SCHEMBL4888175 | 0.93 | AOX1 (0.77) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| Hydrochloric Acid SCHEMBL5953779 | 0.92 | AOX1 (0.75) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| SCHEMBL27874410 | 0.86 | RAD52 (0.74) | AOX1RAD52UHRF1SMARCA2PARP1 | |
| SCHEMBL7023521 | 0.83 | AOX1 (0.69) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| SCHEMBL7032809 | 0.83 | AOX1 (0.69) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| SCHEMBL2447168 | 0.82 | KDM4E (0.69) | AOX1RAD52UHRF1SMARCA2HDAC1 | |
| SCHEMBL7566347 | 0.82 | HDAC1 (0.67) | AOX1RAD52UHRF1SMARCA2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160106743-A1 | TOPOISOMERASE II POISONS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF ROCHESTER (US) | 2016-04-21 | — | — | US | claimed |
| US-20160106743-A1 | TOPOISOMERASE II POISONS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF ROCHESTER (US) | 2016-04-21 | — | — | US | disclosed |
| WO-1998045272-A1 | TOPOISOMERASE INHIBITORS | LATROBE UNIVERSITY (AU) | 1998-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160106743-A1 | TOPOISOMERASE II POISONS AND METHODS OF MAKING AND USING SAME | TOP2A, TOP2B, TOP1 | AOX1 724/4885RAD52 85/4885UHRF1 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.