Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | AHR | P35869 | 1/20 | 0.70 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254980 | 0.90 | TP53 (0.75) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL31680510 | 0.88 | SMN1; SMN2 (0.88) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL24711273 | 0.86 | LMNA (0.86) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL28589695 | 0.85 | ALDH1A1 (0.69) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL18416918 | 0.85 | HTT (0.68) | MEN1KMT2AL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL7245504 | 0.84 | MAPT (0.69) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL28590005 | 0.84 | MEN1 (0.70) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL28579658 | 0.84 | KMT2A (0.67) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL28577326 | 0.84 | KCNMA1 (0.71) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL29886513 | 0.83 | EPHX1 (0.78) | MEN1KMT2AL3MBTL1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |