Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713528 | 0.90 | GABRA5 (0.31) | GABRA5GABRB2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8043579 | 0.87 | MAPT (0.35) | ALDH1A1MAPT | |
| SCHEMBL8044290 | 0.85 | HSD17B10 (0.45) | GABRA5GABRB2HSD17B10LMNAKDM4E | |
| SCHEMBL8046194 | 0.84 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL8043964 | 0.78 | MAPT (0.34) | ALDH1A1MAPT | |
| SCHEMBL8709917 | 0.78 | LMNA (0.33) | GABRA5GABRB2HSD17B10LMNAKDM4E | |
| SCHEMBL8044307 | 0.78 | HSD17B10 (0.47) | GABRA5GABRB2HSD17B10LMNAKDM4E | |
| SCHEMBL8034362 | 0.77 | F2 (0.39) | ALDH1A1MAPT | |
| SCHEMBL8044470 | 0.77 | MAPT (0.33) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8047155 | 0.77 | MAPT (0.37) | HSD17B10LMNAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |