Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.48 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8713875 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL9230536 | 0.97 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL9230534 | 0.97 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| SCHEMBL8711230 | 0.95 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL8711196 | 0.93 | MEN1 (0.48) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL8711194 | 0.93 | MEN1 (0.48) | SMN1; SMN2ALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL8711531 | 0.93 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| Fumaric Acid SCHEMBL8711535 | 0.93 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| Fumaric Acid SCHEMBL9228003 | 0.93 | MEN1 (0.47) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 | |
| Fumaric Acid SCHEMBL9228009 | 0.93 | MEN1 (0.47) | SMN1; SMN2ALDH1A1LMNAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |