SCHEMBL8714019

SCHEMBL8714019

CC(Cc1ccccc1)C(N)C(O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.58
ADRA2A P08913 1/20 0.55
ADRA2C P18825 1/20 0.55
LMNA P02545 1/20 0.55
HIF1A Q16665 1/20 0.55
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.53
TRPA1 O75762 2/20 0.53
SLC6A2 P23975 2/20 0.52
TAAR1 Q96RJ0 2/20 0.52
MAOA P21397 1/20 0.52
SLC6A4 P31645 1/20 0.52
SLC6A3 Q01959 1/20 0.52
SIGMAR1 Q99720 1/20 0.52
CYP2A6 P11509 1/20 0.52
ADORA2A P29274 1/20 0.52
ADORA1 P30542 1/20 0.52
EPHX1 P07099 2/20 0.45
AOC3 Q16853 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714017 1.00 CYP2D6 (0.58) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8713318 0.90 ALDH1A1 (0.52) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8714224 0.90 TAAR1 (0.51) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8714170 0.90 CYP2D6 (0.51) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8716602 0.90 LMNA (0.49) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8713316 0.90 ALDH1A1 (0.52) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8716605 0.90 LMNA (0.49) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8714168 0.90 CYP2D6 (0.51) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8713801 0.90 LMNA (0.49) CYP2D6ADRA2AADRA2CLMNAHIF1A
SCHEMBL8713798 0.90 LMNA (0.49) CYP2D6ADRA2AADRA2CLMNAHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5811293-A CULTURE PRODUCT AS CHEMICAL INTERMEDIATE FOR ANTI-OBESITY AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-22 US disclosed
US-5679557-A Process of asymmetrically reducing 1-phenyl-2-oxo-propane derivatives with microorganisms DAICEL CHEMICAL INDUSTRIES, LIMITED (JP) 1997-10-21 US disclosed