Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714080 | 0.89 | MAPT (0.55) | CREBBPSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4490282 | 0.81 | PPM1D (0.49) | CREBBPSMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL4505041 | 0.79 | MEN1 (0.54) | CREBBPSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4499871 | 0.77 | CREBBP (0.45) | CREBBPSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL8710534 | 0.75 | SIRT2 (0.60) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL26192067 | 0.74 | SMN1; SMN2 (0.46) | CREBBPSMN1; SMN2RAB9AMAPTEP300 | |
| SCHEMBL32678568 | 0.74 | CREBBP (0.44) | CREBBPEP300KMT2AMEN1LMNA | |
| SCHEMBL32678567 | 0.74 | CREBBP (0.44) | CREBBPEP300KMT2AMEN1LMNA | |
| SCHEMBL14052788 | 0.74 | CREBBP (0.48) | CREBBPSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8714422 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1HTTMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |