SCHEMBL8714178

SCHEMBL8714178

COc1ccccc1C(O)C(N)C(C)Cc1ccccc1C

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.39
CYP2D6 P10635 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA1A P35348 1/20 0.38
CHRM2 P08172 1/20 0.37
MEN1 O00255 1/20 0.37
MAPK1 P28482 1/20 0.37
BLM P54132 1/20 0.37
IDO1 P14902 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714177 1.00 KMT2A (0.39) KMT2ACYP2D6ADRA2AADRA1ACHRM2
SCHEMBL8716631 0.93 IDO1 (0.41) KMT2ACYP2D6ADRA2AADRA1ACHRM2
SCHEMBL8716628 0.93 IDO1 (0.41) KMT2ACYP2D6ADRA2AADRA1ACHRM2
SCHEMBL8716176 0.90 IDO1 (0.42) KMT2ACYP2D6ADRA2AADRA1ACHRM2
SCHEMBL8716177 0.90 IDO1 (0.42) KMT2ACYP2D6ADRA2AADRA1ACHRM2
SCHEMBL8714091 0.89 TAAR1 (0.38) CYP2D6ADRA2ATAAR1
SCHEMBL8714092 0.89 TAAR1 (0.38) CYP2D6ADRA2ATAAR1
SCHEMBL8713784 0.85 SLC6A2 (0.42) KMT2ACYP2D6ADRA2AADRA1AMEN1
SCHEMBL8713787 0.85 SLC6A2 (0.42) KMT2ACYP2D6ADRA2AADRA1AMEN1
SCHEMBL8713626 0.85 SGMS2 (0.43) ADRA1AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5811293-A CULTURE PRODUCT AS CHEMICAL INTERMEDIATE FOR ANTI-OBESITY AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-22 US disclosed