Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711180 | 0.87 | ALOX5 (0.64) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL11972732 | 0.86 | ALDH1A1 (0.57) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL11485213 | 0.86 | ALOX5 (0.63) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL13187282 | 0.85 | MEN1 (0.79) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL6035317 | 0.85 | ALDH1A1 (0.79) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL1663559 | 0.84 | ALOX5 (0.64) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL30409295 | 0.84 | MEN1 (0.73) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL11972772 | 0.84 | MEN1 (0.90) | MEN1KMT2AGAAALOX5MAPT | |
| SCHEMBL5151922 | 0.82 | MAPT (0.68) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL5137239 | 0.82 | NPC1 (0.73) | MEN1KMT2AGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8927584-B2 | Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-01-06 | — | — | US | disclosed |
| US-20140046290-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL)BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2014-02-13 | — | — | US | disclosed |
| US-8592603-B2 | Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2013-11-26 | — | — | US | disclosed |
| US-20120215154-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-08-23 | — | — | US | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5278180-A | 4,5-bis(aryl) 4H-1,2,4-triazoles derivatives and analgesic use | ROUSSEL UCLAF (FR) | 1994-01-11 | — | — | US | disclosed |
| EP-0176444-B1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 4H-1,2,4-TRIAZOLE, TRIAZOLES SO OBTAINED, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1989-02-22 | — | — | EP | disclosed |
| EP-0176444-A1 | Process for the preparation of derivatives of 4H-1,2,4-triazole, triazoles so obtained, their use as medicaments, and pharmaceutical compositons containing them | ROUSSEL-UCLAF (FR) | 1986-04-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140046290-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL)BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | CCNT1, PPOX, TPT1 | MEN1 1141/4885KMT2A 2192/4885GAA 1366/4885 |
| US-20120215154-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | HCCS, PAH, PPOX | MEN1 1027/4885KMT2A 627/4885GAA 2093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.