Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS15 | P98073 | 5/20 | 0.39 |
| ▸ | NQO2 | P16083 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407975 | 0.85 | ITGB3 (0.43) | NQO2WDR5ITGB3ITGA2BF2 | |
| SCHEMBL3201821 | 0.81 | MAPT (0.42) | MAPT | |
| SCHEMBL8410938 | 0.80 | F2 (0.41) | TMPRSS15NQO2F2F10PRSS1 | |
| SCHEMBL20545052 | 0.77 | CA12 (0.40) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL3196799 | 0.77 | MAPT (0.45) | ALDH1A1MAPT | |
| SCHEMBL29131295 | 0.77 | MAPT (0.45) | ALDH1A1MAPT | |
| SCHEMBL20545009 | 0.76 | LMNA (0.47) | KDM4EALDH1A1MAPT | |
| SCHEMBL9093411 | 0.76 | PRMT1 (0.63) | F2F10PRSS1 | |
| Hydrochloric Acid SCHEMBL8409252 | 0.76 | PRSS1 (0.63) | F2F10PRSS1 | |
| Hydrochloric Acid SCHEMBL8407932 | 0.76 | HDAC1 (0.47) | TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |