Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048673 | 0.91 | MEN1 (0.40) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8045965 | 0.91 | MEN1 (0.43) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8050933 | 0.85 | LMNA (0.40) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8715721 | 0.84 | ALDH1A1 (0.41) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8044888 | 0.82 | MEN1 (0.53) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8042914 | 0.81 | LMNA (0.43) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL8042172 | 0.79 | ALDH1A1 (0.38) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL8041897 | 0.79 | ALDH1A1 (0.47) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8043692 | 0.78 | HSD17B10 (0.36) | KMT2AMEN1LMNASMN1; SMN2KDM4E | |
| SCHEMBL8044748 | 0.78 | TP53 (0.42) | KMT2AMEN1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |