Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 15/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714845 | 0.81 | HRH3 (0.44) | HRH3KCNH2 | |
| SCHEMBL8304115 | 0.81 | PDE3B (0.47) | NR1H2GRIA2KCNH2 | |
| SCHEMBL11568277 | 0.67 | HRH3 (0.50) | HRH3KCNH2 | |
| SCHEMBL20138742 | 0.67 | HRH3 (0.53) | HRH3KCNH2CYP1A2 | |
| SCHEMBL20159394 | 0.67 | HRH3 (0.50) | HRH3KCNH2 | |
| SCHEMBL10405611 | 0.67 | NR1H2 (0.47) | NR1H2GRIA2 | |
| SCHEMBL8303942 | 0.67 | PDE3B (0.42) | GRIA2KCNH2 | |
| SCHEMBL8720034 | 0.66 | HDAC8 (0.42) | NR1H2GRIA2HRH3CYP1A2 | |
| SCHEMBL8306283 | 0.66 | LMNA (0.47) | NR1H2GRIA2 | |
| SCHEMBL8110725 | 0.66 | SMN1; SMN2 (0.48) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |