SCHEMBL8715367

SCHEMBL8715367

O=C1NC(=O)C(Cc2ccc(OCc3ccccc3)c3ccccc23)S1

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 10/20 0.51
PPARG P37231 3/20 0.48
PPARA Q07869 3/20 0.48
CA2 P00918 2/20 0.46
PTPN1 P18031 1/20 0.43
MAPT P10636 1/20 0.42
MAOB P27338 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8718200 0.88 PPARG (0.47) FFAR1PPARGPPARACA2PTPN1
SCHEMBL13846741 0.86 PPARG (0.51) FFAR1PPARGPPARACA2PTPN1
SCHEMBL9570555 0.85 CA2 (0.48) FFAR1PPARGPPARACA2PTPN1
SCHEMBL13846817 0.85 FFAR1 (0.55) FFAR1PPARGPPARACA2PTPN1
SCHEMBL13846806 0.84 CA2 (0.47) FFAR1PPARGPPARACA2PTPN1
SCHEMBL4099376 0.83 PPARG (0.46) FFAR1PPARGPPARACA2PTPN1
SCHEMBL8228771 0.83 CA2 (0.63) FFAR1PPARGCA2PTPN1MAPT
SCHEMBL8172644 0.82 FFAR1 (0.61) FFAR1PPARGPPARACA2PTPN1
SCHEMBL13846718 0.82 CNR2 (0.47) FFAR1PPARGPPARACA2PTPN1
SCHEMBL9570547 0.81 PPARG (0.57) FFAR1PPARGPPARAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998042691-A1 NEW THIAZOLEDINEDIONES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THE SAME ROCHE DIAGNOSTICS GMBH (DE) 1998-10-01 WO disclosed