Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 14/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715515 | 0.95 | CDK1 (0.50) | CDK1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL17967100 | 0.85 | CDK1 (0.59) | CDK1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL2963284 | 0.78 | ERN1 (0.37) | ERN1TRIM24TYRTRIM33LMNA | |
| SCHEMBL8709353 | 0.76 | ALOX15 (0.38) | — | |
| SCHEMBL11518506 | 0.76 | CDK1 (0.51) | CDK1ERN1TRIM24TYRTRIM33 | |
| Salicyladehyde SCHEMBL1980237 | 0.76 | TRIM24 (0.64) | ERN1TRIM24TYRTRIM33LMNA | |
| SCHEMBL2980854 | 0.74 | ERN1 (0.33) | CDK1ERN1LMNAMAPT | |
| SCHEMBL15543635 | 0.74 | CDK1 (0.71) | CDK1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL9137077 | 0.74 | CDK1 (0.49) | CDK1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL21137127 | 0.73 | KDM4E (0.47) | CDK1ERN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |