Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514820 | 0.98 | LPAR3 (0.44) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL18837389 | 0.83 | LPAR3 (0.42) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| Hydrochloric Acid SCHEMBL7147494 | 0.77 | LPAR2 (0.42) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL1906179 | 0.75 | LPAR2 (0.44) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL1933828 | 0.75 | LPAR3 (0.44) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL6831358 | 0.75 | LPAR2 (0.44) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL16311960 | 0.74 | LPAR2 (0.50) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL18184028 | 0.74 | LPAR2 (0.50) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| SCHEMBL27094088 | 0.74 | LPAR3 (0.46) | LPAR3LPAR2LPAR1FAAHTRPV1 | |
| Bromide SCHEMBL28992163 | 0.73 | LPAR3 (0.42) | LPAR3LPAR2LPAR1FAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964257-B1 | TRANSCUTANEOUS DOSAGE FORMULATION | RES INST NATIONWIDE CHILDRENS HOSPITAL (US) | 2024-10-09 | — | — | EP | disclosed |
| US-12048740-B2 | Transcutaneous dosage formulation | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2024-07-30 | — | — | US | disclosed |
| US-20200330580-A1 | Transcutaneous Dosage Formulation | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | 2020-10-22 | — | — | US | disclosed |
| US-10722568-B2 | Transcutaneous Haemophilius influenzae vaccine formulations and methods | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2020-07-28 | — | — | US | disclosed |
| US-20180071381-A1 | TRANSCUTANEOUS HAEMOPHILIUS INFLUENZAE VACCINE FORMULATIONS AND METHODS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-15 | — | — | US | disclosed |
| US-9855326-B2 | Transcutaneous haemophilus influenzae vaccine formulations and methods | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2018-01-02 | — | — | US | disclosed |
| US-20160022800-A1 | TRANSCUTANEOUS DOSAGE FORMULATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-28 | — | — | US | disclosed |
| EP-2964257-A1 | TRANSCUTANEOUS DOSAGE FORMULATION | Research Institute at Nationwide Children's Hospital (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014138748-A1 | TRANSCUTANEOUS DOSAGE FORMULATION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-09-12 | — | — | WO | disclosed |
| US-20140199350-A1 | CHIMERIC TOPICAL VACCINE FOR HAEMOPHILUS INFLUENZAE-INDUCED DISEASE | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2014-07-17 | — | — | US | disclosed |
| US-8741304-B2 | Chimeric vaccine for Haemophilus influenzae-induced disease | NATIONWIDE CHILDREN'S HOSPITAL | 2014-06-03 | — | — | US | disclosed |
| US-20130064828-A1 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease | NATIONWIDE CHILDREN'S HOSPITAL, INC. (US) | 2013-03-14 | — | — | US | disclosed |
| US-5753477-A | Magneto-biolistic methods | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |