Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6831358 | 0.98 | LPAR2 (0.44) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL1906179 | 0.98 | LPAR2 (0.44) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL1127954 | 0.89 | DNM1 (0.39) | — | |
| SCHEMBL16311960 | 0.78 | LPAR2 (0.50) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL18184028 | 0.78 | LPAR2 (0.50) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| Hydrochloric Acid SCHEMBL8715666 | 0.77 | LPAR3 (0.42) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL25804968 | 0.76 | LPAR1 (0.37) | LPAR2LPAR3LPAR1 | |
| SCHEMBL5514820 | 0.75 | LPAR3 (0.44) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL2301357 | 0.75 | LPAR2 (0.44) | LPAR2LPAR3LPAR1FAAHTRPV1 | |
| SCHEMBL16311959 | 0.74 | ALDH1A1 (0.51) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363670-A1 | POLYNUCLEOTIDE FORMULATION FOR ENHANCED INTRACELLULAR TRANSFER | Aventis Pasteur (FR) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002067990-A1 | POLYNUCLEOTIDE FORMULATION FOR ENHANCED INTRACELLULAR TRANSFER | AVENTIS PASTEUR (FR) | 2002-09-06 | — | — | WO | disclosed |