Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | PTGIR | P43119 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712117 | 0.95 | HSD11B1 (0.59) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL9232680 | 0.92 | HSD11B1 (0.56) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL8711004 | 0.91 | HSD11B1 (0.60) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL8710934 | 0.91 | HSD11B1 (0.54) | HTR2AACHEHSD11B1PTGIR | |
| SCHEMBL8713824 | 0.91 | HSD11B1 (0.54) | HTR2AACHEHSD11B1CYP3A4CYP2D6 | |
| SCHEMBL8710852 | 0.89 | HSD11B1 (0.51) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL8711102 | 0.89 | HSD11B1 (0.51) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL8714509 | 0.89 | HSD11B1 (0.51) | HTR2AACHEHSD11B1KDM4ECYP1A2 | |
| SCHEMBL8716650 | 0.88 | PTGIR (0.52) | HTR2AACHEHSD11B1CYP1A2PTGIR | |
| SCHEMBL8712288 | 0.88 | HSD11B1 (0.53) | HTR2AACHEHSD11B1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |