Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712117 | 0.93 | HSD11B1 (0.59) | HSD11B1HTR2ACYP1A2HTR2CACHE | |
| SCHEMBL8710934 | 0.90 | HSD11B1 (0.54) | PTGIRHSD11B1OPRM1ALDH1A1LMNA | |
| SCHEMBL8716772 | 0.90 | HSD11B1 (0.51) | PTGIRHSD11B1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8713824 | 0.89 | HSD11B1 (0.54) | PTGIRHSD11B1ALDH1A1SMN1; SMN2HTR2A | |
| SCHEMBL8711220 | 0.88 | PTGIR (0.56) | PTGIRHSD11B1OPRM1ALDH1A1LMNA | |
| SCHEMBL8715718 | 0.88 | HTR2A (0.61) | PTGIRHSD11B1HTR2ACYP1A2ACHE | |
| SCHEMBL8716576 | 0.88 | OPRM1 (0.48) | PTGIRHSD11B1OPRM1ALDH1A1LMNA | |
| SCHEMBL8710757 | 0.88 | ALDH1A1 (0.50) | HSD11B1ALDH1A1LMNASMN1; SMN2HTR2A | |
| SCHEMBL8711379 | 0.88 | OPRM1 (0.48) | PTGIRHSD11B1OPRM1ALDH1A1LMNA | |
| SCHEMBL8716705 | 0.88 | HSD11B1 (0.50) | HSD11B1ALDH1A1LMNASMN1; SMN2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |