Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715780 | 0.80 | HCAR3 (0.33) | SMN1; SMN2TDP1 | |
| SCHEMBL8716302 | 0.79 | — | — | |
| SCHEMBL8476120 | 0.72 | ABCC8 (0.40) | ESR1SMN1; SMN2TDP1 | |
| SCHEMBL8719192 | 0.70 | ESR1 (0.30) | ESR1 | |
| SCHEMBL7069104 | 0.69 | ESR1 (0.36) | ESR1 | |
| SCHEMBL8719348 | 0.63 | — | — | |
| SCHEMBL7078582 | 0.61 | ABCC8 (0.42) | ESR1SMN1; SMN2TDP1 | |
| SCHEMBL8716322 | 0.61 | LIMK1 (0.32) | ESR1 | |
| SCHEMBL7069749 | 0.59 | SMN1; SMN2 (0.34) | SMN1; SMN2 | |
| SCHEMBL7075500 | 0.59 | ABCC8 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876379-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997026265-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |