Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712843 | 0.75 | MAPK8 (0.42) | SMN1; SMN2HTTALDH1A1MAPTGAA | |
| Diethylamine SCHEMBL10530301 | 0.68 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1POLBMEN1LMNA | |
| SCHEMBL8663375 | 0.68 | PKN1 (0.58) | SMN1; SMN2ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL7219537 | 0.68 | MEN1 (0.44) | SMN1; SMN2HTTALDH1A1MAPTGAA | |
| SCHEMBL29241631 | 0.66 | ALDH1A1 (0.41) | SMN1; SMN2HTTALDH1A1MAPTGAA | |
| SCHEMBL30739950 | 0.66 | TDP1 (0.49) | SMN1; SMN2HTTALDH1A1MAPTGAA | |
| SCHEMBL25808876 | 0.66 | PKMYT1 (0.41) | SMN1; SMN2ALDH1A1KDM4EKDM5AMAPT | |
| SCHEMBL24029084 | 0.65 | PRKCZ (0.42) | KDM4EKDM5AHPGDALOX15PARP1 | |
| SCHEMBL7217888 | 0.65 | TDP1 (0.41) | SMN1; SMN2HTTALDH1A1MAPTGAA | |
| Dimethylamine SCHEMBL8760874 | 0.63 | HCAR3 (0.39) | SMN1; SMN2HTTALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |