Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30942655 | 0.94 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL6575309 | 0.94 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL2728205 | 0.88 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29370265 | 0.88 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4551781 | 0.88 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1950952 | 0.81 | DRD2 (0.51) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL16252312 | 0.80 | TDP1 (0.51) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL24773358 | 0.77 | GRIN2B (0.52) | PNMTADRA2AADRA2BADRA2CGRIN2B | |
| SCHEMBL3581953 | 0.77 | HDAC8 (0.38) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL467795 | 0.77 | GRIN2B (0.55) | PNMTADRA2AADRA2BADRA2CGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552817-B1 | Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses | SANKYO CO (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5604182-A | EXHIBIT ANTHELMINTIC, ACARICIDAL AND INSECTICIDAL ACTIVITIES | SANKYO COMPANY LIMITED (JP) | 1997-02-18 | — | — | US | disclosed |
| US-5346918-A | Anthelmintics, acaridices, insecticides | SANKYO COMPANY LIMITED (JP) | 1994-09-13 | — | — | US | disclosed |
| EP-0552817-A2 | Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses | Sankyo Company Limited (JP) | 1993-07-28 | — | — | EP | disclosed |
| EP-0448243-A1 | Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses | Sankyo Company Limited (JP) | 1991-09-25 | — | — | EP | disclosed |