Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.51 |
| ▸ | CTSS | P25774 | 8/20 | 0.51 |
| ▸ | CTSK | P43235 | 7/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8696145 | 0.90 | ITGB3 (0.51) | CTSLCTSSCTSBHDAC8ITGB3 | |
| SCHEMBL8693495 | 0.90 | ITGB3 (0.51) | CTSLCTSSCTSBHDAC8ITGB3 | |
| SCHEMBL8692584 | 0.90 | ITGB3 (0.51) | CTSLCTSSCTSBHDAC8ITGB3 | |
| SCHEMBL8692591 | 0.90 | ITGB3 (0.51) | CTSLCTSSCTSBHDAC8ITGB3 | |
| SCHEMBL7866955 | 0.86 | CAPN1 (0.50) | HDAC8ITGB3ITGA2B | |
| SCHEMBL7286309 | 0.86 | TACR1 (0.54) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL7286303 | 0.86 | TACR1 (0.54) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL8692947 | 0.84 | CTSL (0.52) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL8695637 | 0.83 | GPR132 (0.56) | CTSLCTSBITGB3ITGA2B | |
| SCHEMBL10443977 | 0.81 | CTSL (0.57) | CTSLCTSSCTSKCTSBTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763577-A | ANTICARCINOGENIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0725790-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE DAVIS & COMPANY (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011917-A1 | SUBSTITUTED TETRA- AND PENTAPEPTIDE INHIBITORS OF PROTEIN:FARNESYL TRANSFERASE | PARKE, DAVIS & COMPANY (US) | 1995-05-04 | — | — | WO | disclosed |