SCHEMBL8716672

SCHEMBL8716672

Cc1ccc([SiH3])c(Cl)c1C

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.35
CHRM1 P11229 1/20 0.35
ALOX15 P16050 1/20 0.35
MAOA P21397 1/20 0.35
TBXA2R P21731 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
TSHR P16473 1/20 0.31
TDP2 O95551 1/20 0.31
NSD2 O96028 1/20 0.31
HSP90AA1 P07900 1/20 0.31
PAX8 Q06710 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6441444 0.77 CYP3A4 (0.41) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL1053930 0.75 CYP1A2 (0.35) CYP1A2CYP2A6TSHRTDP2NSD2
SCHEMBL258271 0.72 CYP3A4 (0.39) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL10583579 0.72 CYP3A4 (0.34) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL13905953 0.70 ACHE (0.38) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL8441919 0.69 PON1 (0.33)
SCHEMBL6403160 0.68 CYP3A4 (0.46) CYP3A4ALOX15TSHR
SCHEMBL1157142 0.68 CYP3A4 (0.46) CYP3A4CHRM1ALOX15MAOATBXA2R
SCHEMBL237637 0.68 CYP3A4 (0.35) CYP3A4HTR2BCYP2A6
SCHEMBL30394748 0.68 NOTUM (0.37) CYP3A4CHRM1ALOX15MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4116338-B1 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING SAME LIFE TECHNOLOGIES CORP (US) 2025-06-11 EP disclosed
US-12122859-B2 Hydrophilic polymeric particles and methods for making and using same LIFE TECHNOLOGIES AS (NO) 2024-10-22 US disclosed
EP-3702383-B1 POLYMER SUBSTRATES FORMED FROM CARBOXY FUNCTIONAL ACRYLAMIDE LIFE TECHNOLOGIES CORP (US) 2023-12-27 EP disclosed
US-20230167210-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same Life Technologies Corporation 2023-06-01 US disclosed
US-11572427-B2 Hydrophilic polymeric particles and methods for making and using same Life Technologies Corporation (US) 2023-02-07 US disclosed
EP-4116338-A1 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING SAME Life Technologies Corporation (US) 2023-01-11 EP disclosed
EP-2812360-B1 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING SAME LIFE TECHNOLOGIES CORP (US) 2022-08-31 EP disclosed
US-20210155726-A1 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING AND USING SAME LIFE TECHNOLOGIES AS (NO) 2021-05-27 US disclosed
US-10947333-B2 Hydrophilic polymeric particles and methods for making and using same Life Technologies Corporation (US) 2021-03-16 US disclosed
EP-3702383-A1 POLYMER SUBSTRATES FORMED FROM CARBOXY FUNCTIONAL ACRYLAMIDE Life Technologies Corporation (US) 2020-09-02 EP disclosed
US-9156925-B2 Hydrophilic polymeric particles and methods for making and using same Life Technologies Corporation (US) 2015-10-13 US disclosed
US-9139665-B2 Hydrophilic polymeric particles and methods for making and using same Life Technologies Corporation (US) 2015-09-22 US disclosed
US-9139666-B2 Hydrophilic polymeric particles and methods for making and using same Life Technologies Corporation (US) 2015-09-22 US disclosed
EP-2812360-A2 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING SAME Life Technologies Corporation (US) 2014-12-17 EP disclosed
US-20140142254-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same LIFE TECHNOLOGIES AS (NO) 2014-05-22 US disclosed
US-20140073715-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same LIFE TECHNOLOGIES AS (NO) 2014-03-13 US disclosed
US-20140073738-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same LIFE TECHNOLOGIES AS (US) 2014-03-13 US disclosed
US-20130210991-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same Life Technologies Corporation (US) 2013-08-15 US disclosed
WO-2013119936-A2 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING SAME Life Technologies Corporation (US) 2013-08-15 WO disclosed
US-5705302-A MULTILAYER ELEMENT WITH OPTICALLY TRANSPARENT SUBSTRATE, A CONDUCTIVE LAYER, COLOR LAYER WITH RED GREEN AND BLUE PIXELS SEIKO EPSON CORPORATION (JP) 1998-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167210-A1 Hydrophilic Polymeric Particles and Methods for Making and Using Same CD44, CD68, MTDH CYP3A4 3654/4885CHRM1 2174/4885ALOX15 1267/4885
US-10947333-B2 Hydrophilic polymeric particles and methods for making and using same CD44, CD68, MTDH CYP3A4 3654/4885CHRM1 2174/4885ALOX15 1267/4885
US-20210155726-A1 HYDROPHILIC POLYMERIC PARTICLES AND METHODS FOR MAKING AND USING SAME CD44, CD68, MTDH CYP3A4 3654/4885CHRM1 2174/4885ALOX15 1267/4885
US-11572427-B2 Hydrophilic polymeric particles and methods for making and using same CD44, CD68, MTDH CYP3A4 3654/4885CHRM1 2174/4885ALOX15 1267/4885
US-12122859-B2 Hydrophilic polymeric particles and methods for making and using same CD44, CD68, MTDH CYP3A4 3654/4885CHRM1 2174/4885ALOX15 1267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.