Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 2/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19889483 | 0.89 | LMNA (0.44) | PPM1DLOXL2MRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL18105999 | 0.89 | LMNA (0.44) | PPM1DLOXL2MRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL4505041 | 0.88 | MEN1 (0.54) | MRGPRX4CREBBPEP300ALDH1A1RAB9A | |
| SCHEMBL26192067 | 0.85 | SMN1; SMN2 (0.46) | MRGPRX4CREBBPEP300MAPTRAB9A | |
| SCHEMBL3809200 | 0.85 | KMT2A (0.48) | LOXL2CREBBPEP300TSHRKDM4E | |
| SCHEMBL4456107 | 0.84 | TSHR (0.46) | CREBBPEP300TSHRALDH1A1MAPT | |
| SCHEMBL4315290 | 0.83 | CREBBP (0.58) | PPM1DCREBBPEP300KDM4EALDH1A1 | |
| SCHEMBL10923937 | 0.82 | MRGPRX4 (0.50) | PPM1DMRGPRX4CYP4F2CYP4A11HPGD | |
| SCHEMBL10235987 | 0.82 | ALDH1A1 (0.49) | CREBBPEP300ALDH1A1RAB9AHPGD | |
| SCHEMBL3640912 | 0.82 | ALDH1A1 (0.46) | PPM1DCREBBPEP300ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
| WO-2009136001-A1 | PROTEIN KINASE MODULATING AGENTS | TUOMINEN RAIMO (FI) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | PPM1D 4471/4885LOXL2 2411/4885MRGPRX4 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.