SCHEMBL8717428

SCHEMBL8717428

O=C(O)[C@@H]1CCCN(CC=C2c3ccccc3COc3ccccc32)C1

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 2/20 0.60
HRH1 P35367 2/20 0.60
LTA4H P09960 3/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
TSHR P16473 1/20 0.45
NFKB1 P19838 1/20 0.45
CYP2C19 P33261 1/20 0.45
HSD17B10 Q99714 1/20 0.45
SLC6A1 P30531 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7609379 0.99 TBXA2R (0.59) TBXA2RHRH1LTA4H
SCHEMBL6971107 0.87 TBXA2R (0.60) TBXA2RHRH1CYP1A2CYP2D6TSHR
SCHEMBL8717411 0.87 SLC6A1 (0.53) CYP1A2CYP2D6CYP2C9TSHRNFKB1
Oxalic Acid SCHEMBL8720463 0.87 TBXA2R (0.53) TBXA2RHRH1CYP1A2CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL7604196 0.86 SLC6A1 (0.52) CYP1A2CYP2D6CYP2C9TSHRNFKB1
SCHEMBL9130146 0.81 HRH1 (0.56) TBXA2RHRH1CYP1A2CYP2D6TSHR
SCHEMBL9130158 0.81 HRH1 (0.56) TBXA2RHRH1CYP1A2CYP2D6TSHR
SCHEMBL6957114 0.80 SLC6A1 (0.44) TBXA2RHRH1CYP1A2CYP2D6CYP2C9
SCHEMBL6963106 0.80 SLC6A1 (0.44) TBXA2RHRH1CYP1A2CYP2D6CYP2C9
SCHEMBL7466181 0.80 SLC6A1 (0.56) CYP1A2CYP2D6CYP2C9TSHRNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869777-A1 NOVEL METHOD NOVO NORDISK A/S (DK) 1998-10-14 EP disclosed
WO-1997022338-A1 NOVEL METHOD NOVO NORDISK A/S (DK) 1997-06-26 WO disclosed