Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789518 | 1.00 | PRCP (0.50) | PRCPSLC22A1OPRM1SMN1; SMN2SIGMAR1 | |
| SCHEMBL8790382 | 0.92 | OPRM1 (0.49) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E | |
| SCHEMBL9373834 | 0.85 | PRCP (0.51) | PRCPSLC22A1OPRM1SMN1; SMN2SIGMAR1 | |
| SCHEMBL9373828 | 0.85 | PRCP (0.51) | PRCPSLC22A1OPRM1SMN1; SMN2SIGMAR1 | |
| SCHEMBL9373842 | 0.85 | PRCP (0.51) | PRCPSLC22A1OPRM1SMN1; SMN2SIGMAR1 | |
| SCHEMBL3453173 | 0.81 | OPRM1 (0.56) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E | |
| SCHEMBL329828 | 0.80 | OPRM1 (0.57) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E | |
| SCHEMBL329925 | 0.80 | OPRM1 (0.57) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E | |
| SCHEMBL330238 | 0.80 | OPRM1 (0.57) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E | |
| SCHEMBL9423819 | 0.79 | PRCP (0.56) | PRCPSLC22A1OPRM1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569802-B1 | Arylacetamides | MERCK PATENT GMBH (DE) | 1998-07-15 | — | — | EP | disclosed |
| US-5532266-A | Acrylacetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5472961-A | Acetamides | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-12-05 | — | — | US | disclosed |
| EP-0670318-A2 | Acetamides with analgesic and neuroprotective activity | MERCK PATENT GmbH (DE) | 1995-09-06 | — | — | EP | disclosed |
| EP-0569802-A1 | Arylacetamides | MERCK PATENT GmbH (DE) | 1993-11-18 | — | — | EP | disclosed |