Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839972 | 0.77 | TSHR (0.74) | TSHRRAB9AHSD17B10MEN1KMT2A | |
| SCHEMBL9838672 | 0.77 | TSHR (0.51) | TSHRRAB9AHSD17B10LTA4HMEN1 | |
| SCHEMBL9838885 | 0.77 | TSHR (0.74) | TSHRRAB9AHSD17B10MEN1KMT2A | |
| SCHEMBL9838876 | 0.77 | TSHR (0.74) | TSHRRAB9AHSD17B10MEN1KMT2A | |
| SCHEMBL9869891 | 0.77 | TSHR (0.51) | TSHRRAB9AHSD17B10LTA4HMEN1 | |
| SCHEMBL5742123 | 0.71 | CA1 (0.56) | TSHRKMT2ATACR1MAPK1HTT | |
| SCHEMBL4663018 | 0.70 | LTA4H (0.60) | TSHRRAB9AHSD17B10LTA4HLMNA | |
| SCHEMBL18723710 | 0.69 | LTA4H (0.52) | RAB9ALTA4HLMNAKDM4EALDH1A1 | |
| SCHEMBL22571978 | 0.69 | CA1 (0.54) | TSHRKMT2ATACR1MAPK1HTT | |
| SCHEMBL6930625 | 0.69 | CA1 (0.50) | TSHRMEN1KMT2AKDM4ETACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858335-A1 | 2-ALKYLPYRROLIDINES | NOVO NORDISK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997009040-A1 | 2-ALKYLPYRROLIDINES | NOVO NORDISK A/S (DK) | 1997-03-13 | — | — | WO | disclosed |