Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.79 |
| ▸ | PGR | P06401 | 4/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.79 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.79 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.79 |
| ▸ | TNF | P01375 | 1/20 | 0.79 |
| ▸ | IL6 | P05231 | 1/20 | 0.79 |
| ▸ | AR | P10275 | 1/20 | 0.79 |
| ▸ | GLUL | P15104 | 1/20 | 0.79 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.79 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL704873 | 1.00 | HIF1A (0.80) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL8432080 | 1.00 | HIF1A (0.80) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL122047 | 0.94 | NR3C1 (0.88) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL2234173 | 0.94 | NR3C1 (0.88) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone Hemisuccinate SCHEMBL3710487 | 0.92 | HIF1A (0.94) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL7095393 | 0.92 | HIF1A (0.81) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL7999833 | 0.91 | NR3C1 (0.82) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone Hemisuccinate SCHEMBL122046 | 0.89 | HIF1A (1.00) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone Hemisuccinate SCHEMBL871872 | 0.89 | HIF1A (1.00) | HIF1ALMNANR3C1HSD17B10PGR | |
| Prednisolone SCHEMBL35448 | 0.89 | NR3C1 (0.90) | HIF1ALMNANR3C1HSD17B10PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10072352-A | — | — | None | — | — | JP | disclosed |
| JP-10072352-A | — | — | None | — | — | JP | disclosed |
| WO-2019163838-A1 | MARKER FOR MULTIPLE SCLEROSIS | 国立研究開発法人理化学研究所 | 2019-08-29 | — | — | WO | disclosed |
| JP-H1072352-A | INFECTION SOLUTION OF PREDNISOLONE SODIUM METHYL SUCCINATE | NIPPON KAYAKU CO LTD | 1998-03-17 | — | — | JP | disclosed |
| JP-H1072352-A | INFECTION SOLUTION OF PREDNISOLONE SODIUM METHYL SUCCINATE | NIPPON KAYAKU CO LTD | 1998-03-17 | — | — | JP | disclosed |