Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Prednisolone Hemisuccinate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 0.78 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | AR | P10275 | 2/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | TNF | P01375 | 1/20 | 0.70 |
| ▸ | IL6 | P05231 | 1/20 | 0.70 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.70 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.70 |
| ▸ | GLUL | P15104 | 1/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.70 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone Hemisuccinate SCHEMBL122046 | 1.00 | HIF1A (1.00) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL3710487 | 0.97 | HIF1A (0.94) | HIF1ALMNAPGRPMP22TSHR | |
| SCHEMBL16009510 | 0.95 | HIF1A (0.91) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL945987 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL13026153 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL25138782 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| SCHEMBL16170220 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| SCHEMBL3268865 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL12540510 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR | |
| Prednisolone Hemisuccinate SCHEMBL16009511 | 0.92 | HIF1A (0.85) | HIF1ALMNAPGRPMP22TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1744683-B1 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA CORP (US) | 2016-03-16 | — | — | EP | claimed |
| US-8361022-B2 | Apparatus for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2013-01-29 | — | — | US | claimed |
| US-20100152649-A1 | Apparatus and method for transdermal delivery of parathyroid hormone agents | ALZA CORPORATION (US) | 2010-06-17 | — | — | US | claimed |
| EP-1706176-A4 | FREQUENCY ASSISTED TRANSDERMAL AGENT DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-06-25 | — | — | EP | claimed |
| EP-1686904-A4 | ULTRASOUND ASSISTED TRANSDERMAL VACCINE DELIVERY METHOD AND SYSTEM | ALZA CORP (US) | 2008-02-27 | — | — | EP | claimed |
| EP-1680178-A4 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORP (US) | 2008-01-02 | — | — | EP | claimed |
| JP-2007530680-A | — | — | 2007-11-01 | — | — | JP | claimed |
| EP-1744683-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF PARATHYROID HORMONE AGENTS | ALZA Corporation (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1737434-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF FENTANYL-BASED AGENTS | ALZA CORPORATION (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1735469-A2 | APPARATUS AND METHOD FOR TRANSDERMAL DELIVERY OF MULTIPLE VACCINES | ALZA Corporation (US) | 2006-12-27 | — | — | EP | claimed |
| US-20050112135-A1 | Ultrasound assisted transdermal vaccine delivery method and system | ALZA CORPORATION | 2005-05-26 | — | — | US | claimed |
| WO-2005044366-A2 | SYSTEM AND METHOD FOR TRANSDERMAL VACCINE DELIVERY | ALZA CORPORATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005042702-A2 | COMPOSITIONS OF STABILIZED DNA FOR COATING MICROPROJECTIONS | ALZA CORPORATION (US) | 2005-05-12 | — | — | WO | claimed |
| US-20050090009-A1 | Compositions of stabilized DNA for coating microprojctions | ALZA CORPORATION | 2005-04-28 | — | — | US | claimed |
| US-20050049549-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-03-03 | — | — | US | claimed |
| WO-2005016440-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016441-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| US-20050031676-A1 | Method and device for enhancing transdermal agent flux | ALZA CORPORATION | 2005-02-10 | — | — | US | claimed |
| US-20050025778-A1 | Microprojection array immunization patch and method | ALZA CORPORATION | 2005-02-03 | — | — | US | claimed |
| WO-2005002453-A1 | MICROPROJECTION ARRAY IMMUNIZATION PATCH AND METHOD | ALZA CORPORATION (US) | 2005-01-13 | — | — | WO | claimed |