Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11664388 | 0.81 | LMNA (0.41) | LMNAFDPSEPHX1CA2MMP2 | |
| SCHEMBL8985384 | 0.79 | EPHX1 (0.39) | LMNAFDPSEPHX1CA2MMP2 | |
| SCHEMBL28305379 | 0.73 | LMNA (0.35) | LMNAFDPSEPHX1 | |
| SCHEMBL8720991 | 0.70 | HDAC3 (0.43) | FDPSCA2MMP2MMP8CA12 | |
| SCHEMBL11659802 | 0.69 | PKM (0.34) | FDPSCA2MMP2MMP8CA12 | |
| Phosphoric Acid SCHEMBL27902534 | 0.69 | KDM4E (0.38) | EPHX1KDM4EPKM | |
| SCHEMBL124179 | 0.67 | — | — | |
| SCHEMBL27265453 | 0.67 | EPHX1 (0.42) | LMNAEPHX1CA2KDM4EPTGS1 | |
| SCHEMBL6363154 | 0.67 | — | — | |
| SCHEMBL11664344 | 0.67 | LMNA (0.43) | LMNAFDPSCA2MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570380-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1998-09-16 | — | — | EP | disclosed |
| US-5442101-A | Treatment of calcium metabolism disorders, bone disorders | LEIRAS OY (FI) | 1995-08-15 | — | — | US | disclosed |
| EP-0570380-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1993-11-24 | — | — | EP | disclosed |
| WO-1992011268-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |