SCHEMBL8718494

SCHEMBL8718494

COc1ccc(-n2cn[nH]c2=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 1/20 0.51
ALDH1A1 P00352 2/20 0.47
ATM Q13315 1/20 0.47
PKM P14618 1/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C9 P11712 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
HTT P42858 3/20 0.46
MGLL Q99685 1/20 0.46
XDH P47989 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
POLB P06746 1/20 0.44
GAA P10253 2/20 0.44
CYP11B2 P19099 1/20 0.43
TNF P01375 1/20 0.43
NOTUM Q6P988 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3117217 0.91 MAPT (0.52) ALDH1A1L3MBTL1MEN1KMT2AGAA
SCHEMBL8718365 0.81 CYP11B2 (0.47) HTTKMT2AGAACYP11B2NOTUM
SCHEMBL8931695 0.80 MAPT (0.56) ALDH1A1CYP1A2CYP2C9L3MBTL1KMT2A
SCHEMBL1618003 0.79 HTT (0.50) HCAR1ALDH1A1PKMHTTMGLL
SCHEMBL8931663 0.79 GPR119 (0.55) ALDH1A1L3MBTL1MEN1KMT2AGAA
SCHEMBL8931690 0.79 GPR119 (0.58) ALDH1A1MEN1KMT2AGAAMAPT
SCHEMBL8718833 0.78 POLB (0.56) L3MBTL1HTTPOLBNOTUMLMNA
SCHEMBL4778468 0.77 HTT (0.51) HCAR1ALDH1A1PKMHTTTNF
SCHEMBL9383839 0.77 MAPT (0.43) ALDH1A1KMT2AGAALMNAMAPT
SCHEMBL15912767 0.77 ALDH1A1 (0.47) ALDH1A1L3MBTL1GAALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0567982-B1 Azole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-07-01 EP disclosed
US-5371101-A Fungicides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-06 US disclosed
EP-0567982-A1 Azole compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1993-11-03 EP disclosed