Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032980 | 0.80 | ALDH1A1 (0.56) | CES2MGLLTSHRALDH1A1ACP3 | |
| SCHEMBL62723 | 0.78 | TSHR (0.67) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL6317752 | 0.76 | TSHR (0.54) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL22932515 | 0.76 | TSHR (0.54) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL25489557 | 0.76 | TSHR (0.54) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL26394809 | 0.76 | TSHR (0.45) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL8120662 | 0.76 | KCNN4 (0.47) | CES2ALDH1A1CHRM3CYP19A1 | |
| Methyl Alcohol SCHEMBL9419583 | 0.75 | TSHR (0.58) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL30252943 | 0.75 | TSHR (0.64) | CES2MGLLTSHRMAPK1HTR3E | |
| SCHEMBL30553105 | 0.75 | TSHR (0.64) | CES2MGLLTSHRMAPK1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613475-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0613475-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS. | PPG INDUSTRIES INC (US) | 1995-02-08 | — | — | EP | disclosed |
| EP-0613475-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010112-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1993-05-27 | — | — | WO | disclosed |
| US-5066818-A | Lenses, plastic transparencies | PPG INDUSTRIES, INC. (US) | 1991-11-19 | — | — | US | disclosed |