Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775110 | 0.73 | AKR1B1 (0.45) | ALDH1A1LMNAKMT2AFFAR1FFAR4 | |
| SCHEMBL14775107 | 0.73 | FFAR1 (0.45) | ALDH1A1LMNAKMT2AFFAR1FFAR4 | |
| SCHEMBL9128675 | 0.69 | TP53 (0.42) | ALDH1A1KMT2AFFAR1FFAR4IDO1 | |
| SCHEMBL52407 | 0.69 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2AIDO1 | |
| SCHEMBL17554271 | 0.68 | FFAR1 (0.41) | ALDH1A1LMNAKMT2AFFAR1FFAR4 | |
| SCHEMBL18025779 | 0.67 | ALOX12 (0.42) | ALDH1A1LMNAKMT2AIDO1 | |
| SCHEMBL6260611 | 0.67 | ALDH1A1 (0.40) | ALDH1A1LMNAKMT2AIDO1NOS3 | |
| SCHEMBL8041951 | 0.67 | HCAR2 (0.45) | ALDH1A1LMNAIDO1NOS1 | |
| SCHEMBL15151134 | 0.67 | CYP1A2 (0.40) | LMNAFFAR1 | |
| SCHEMBL2557228 | 0.66 | TP53 (0.44) | ALDH1A1FFAR1FFAR4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722448-A4 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693648-A | TREATMENT OF AUTOIMMUNE DISEASES, INFECTIOUS DISEASES, PREVENTING REJECTION OF ORGAN TRANSPLANTS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5565560-A | TREATING AUTOIMMUNE DISEASES, PREVENTING TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0722448-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO. INC. (US) | 1996-07-24 | — | — | EP | disclosed |
| US-5532248-A | O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity | MERCK CO., INC. (US) | 1996-07-02 | — | — | US | disclosed |
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| US-5250678-A | For autoimmune, infectious diseases, organ transplant rejection; skin diseases, antiinflammatory agents | MERCK & CO., INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | disclosed |