SCHEMBL8718685

SCHEMBL8718685

O=[N+]([O-])c1ccc(O)c(CN2CCNCCNCCNCC2)c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSB P07858 1/20 0.70
ALDH1A1 P00352 4/20 0.50
LMNA P02545 2/20 0.50
KDM4E B2RXH2 2/20 0.50
KCNJ1 P48048 1/20 0.50
KCNH2 Q12809 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
NOX4 Q9NPH5 1/20 0.48
CDK1 P06493 1/20 0.46
CCNB1 P14635 1/20 0.46
ADRB1 P08588 1/20 0.46
SIRT6 Q8N6T7 1/20 0.46
MAPT P10636 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
TP53 P04637 1/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
GPR35 Q9HC97 1/20 0.43
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22773553 0.99 CTSB (0.71) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL21044031 0.89 CTSB (0.60) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL25416781 0.82 CTSB (0.71) CTSBALDH1A1LMNAKDM4ESMN1; SMN2
SCHEMBL922732 0.82 CTSB (1.00) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL10692339 0.81 CTSB (0.97) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL10692345 0.81 CTSB (0.97) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL24672943 0.81 SOS1 (0.46) CTSBALDH1A1LMNATSHR
SCHEMBL8715361 0.81 KCNJ1 (0.55) CTSBALDH1A1LMNAKDM4EKCNJ1
SCHEMBL21044045 0.80 CTSB (0.68) CTSBALDH1A1LMNAKDM4ESMN1; SMN2
SCHEMBL8714933 0.80 CTSB (0.68) CTSBALDH1A1LMNAKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756065-A DIAGNOSTIC CHELATES FOR ANTIBODIES AND RADIOACTIVE MATERIALS THE DOW CHEMICAL COMPANY (US) 1998-05-26 US disclosed
US-5652361-A ANTITUMOR THE DOW CHEMICAL COMPANY (US) 1997-07-29 US disclosed
US-5435990-A Chelate-antibody complexes, treatment and diagnosis of cancer, tetraazacyclododecane compounds THE DOW CHEMICAL COMPANY (US) 1995-07-25 US disclosed
EP-0353450-B1 Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates DOW CHEMICAL CO (US) 1995-03-29 EP disclosed
EP-0420942-A1 MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES THE DOW CHEMICAL COMPANY (US) 1991-04-10 EP disclosed
EP-0353450-A1 Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates THE DOW CHEMICAL COMPANY (US) 1990-02-07 EP disclosed
WO-1989012631-A1 MACROCYCLIC BIFUNCTIONAL CHELANTS, COMPLEXES THEREOF AND THEIR ANTIBODY CONJUGATES THE DOW CHEMICAL COMPANY (US) 1989-12-28 WO disclosed