Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718972 | 0.79 | AR (0.41) | SPHK1SPHK2SMN1; SMN2KMT2ADPP4 | |
| SCHEMBL4723427 | 0.78 | SPHK1 (0.66) | SPHK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31173557 | 0.75 | ALDH1A1 (0.53) | SPHK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6163270 | 0.75 | SPHK1 (0.47) | SPHK1SPHK2FKBP1AACEDPP4 | |
| SCHEMBL30851510 | 0.75 | LGMN (0.39) | SPHK1SPHK2CYP2C19FKBP1AACE | |
| SCHEMBL28504235 | 0.74 | SPHK1 (0.50) | SPHK1SPHK2SMN1; SMN2CYP2C19FKBP1A | |
| SCHEMBL28505919 | 0.74 | SPHK1 (0.50) | SPHK1SPHK2SMN1; SMN2CYP2C19FKBP1A | |
| SCHEMBL408684 | 0.73 | SPHK1 (0.71) | SPHK1CYP2C19ACE | |
| SCHEMBL408685 | 0.73 | SPHK1 (0.71) | SPHK1CYP2C19ACE | |
| SCHEMBL5154674 | 0.73 | SPHK1 (0.71) | SPHK1CYP2C19ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807870-A | SIDE EFFECT REDUCTION | BIOMEGA BOEHRINGER INGELHEIM RESEARCH LTD. (CA) | 1998-09-15 | — | — | US | disclosed |
| US-5614533-A | Substituted pipecolinic acid derivatives as HIV protease inhibitors | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH, INC. (CA) | 1997-03-25 | — | — | US | disclosed |