Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392385 | 0.76 | HTT (0.31) | — | |
| SCHEMBL1799677 | 0.75 | HPGD (0.33) | HPGDCES2CES1LMNAGAA | |
| SCHEMBL8718920 | 0.75 | HPGD (0.33) | HPGDCES2CES1LMNAGAA | |
| SCHEMBL2471234 | 0.75 | HPGD (0.33) | HPGDCES2CES1LMNAGAA | |
| SCHEMBL6142770 | 0.75 | HPGD (0.33) | HPGDCES2CES1LMNAGAA | |
| SCHEMBL2928916 | 0.73 | CES2 (0.35) | CES2CES1LMNA | |
| SCHEMBL29153820 | 0.73 | CES2 (0.35) | CES2CES1LMNA | |
| SCHEMBL29153821 | 0.73 | CES2 (0.35) | CES2CES1LMNA | |
| SCHEMBL11104413 | 0.70 | HPGD (0.33) | HPGDCES2CES1LMNAGAA | |
| SCHEMBL16446965 | 0.70 | HPGD (0.33) | HPGDCES2CES1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821357-A | REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST TWO MOLAR EQUIVALENTS OF METAL DERIVATIVE OF NUCLEOBASE IN LOW FREEZING INERT SOLVENT | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5401838-A | Reaction of sulfonate furanose with nucleobase | ELI LILLY AND COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| US-5371210-A | Reacting alpha anomer enriched 2-deoxy-2,2-difluorocarbo-hydrate with nucleobase | ELI LILLY AND COMPANY (US) | 1994-12-06 | — | — | US | disclosed |