Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | NT5E | P21589 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720615 | 0.98 | BRD4 (0.58) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL9408571 | 0.86 | BRAF (0.49) | BRD4NPC1RAB9ABRAFCYP1A2 | |
| SCHEMBL9408577 | 0.84 | BRAF (0.50) | BRD4NPC1RAB9ABRAFCYP1A2 | |
| SCHEMBL29475418 | 0.81 | BRAF (0.72) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL536913 | 0.81 | BRAF (0.72) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL27204265 | 0.80 | BRD4 (0.55) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL8718988 | 0.80 | SYK (0.46) | NPC1RAB9ABRAFHSD17B10 | |
| SCHEMBL22118772 | 0.80 | BRD4 (0.68) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL5437612 | 0.78 | BRD4 (0.62) | BRD4NPC1RAB9ABRAFNT5C2 | |
| SCHEMBL1358803 | 0.78 | SYK (0.46) | NPC1RAB9ABRAFHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821357-A | REACTING ALPHA-ANOMER ENRICHED 2,2-DIFLUOROCARBOHYDRATE WITH AT LEAST TWO MOLAR EQUIVALENTS OF METAL DERIVATIVE OF NUCLEOBASE IN LOW FREEZING INERT SOLVENT | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0577303-B1 | Stereoselective glycosylation process | LILLY CO ELI (US) | 1997-10-01 | — | — | EP | disclosed |