Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 14/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306283 | 0.81 | LMNA (0.47) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8718572 | 0.77 | PSEN1 (0.41) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8720091 | 0.76 | HRH3 (0.41) | HRH3GRIA2 | |
| SCHEMBL8307326 | 0.75 | HDAC8 (0.51) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8302585 | 0.75 | MAPT (0.46) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8719932 | 0.73 | ALDH1A1 (0.42) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8308772 | 0.71 | HDAC8 (0.46) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8308839 | 0.70 | PSEN1 (0.69) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8307491 | 0.68 | GRIA2 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8715413 | 0.68 | HDAC8 (0.65) | HDAC8PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |