Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dyphylline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B known ✓ | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C known ✓ | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyphylline SCHEMBL10890402 | 0.99 | LMNA (0.78) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Dyphylline SCHEMBL30434822 | 0.95 | LMNA (0.72) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Proxyphylline SCHEMBL28086639 | 0.88 | LMNA (0.77) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Dyphylline SCHEMBL1816552 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Dyphylline SCHEMBL8192 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Dyphylline SCHEMBL123781 | 0.88 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Dyphylline SCHEMBL27937456 | 0.86 | LMNA (0.97) | LMNASMN1; SMN2POLBADORA2BMAPT | |
| Dyphylline SCHEMBL5595886 | 0.84 | LMNA (0.55) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Dyphylline SCHEMBL5194181 | 0.83 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Dyphylline SCHEMBL13724353 | 0.83 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741511-A | Transdermal drug delivery device for treating erectile dysfunction | SAM YANG CO., LTD. (KR) | 1998-04-21 | — | — | US | disclosed |